William Shain, PhD

Publications

• Jhaveri SJ, W Senaratne, MR Hynd, JN Turner, P Sengupta, W Shain, CK Ober. (2006) Defining the biology-materials interface using both 2D and 3D lithography. J. Photopolymer Sci. and Tech. 19: 435-440.
• Hynd, MR, JP Frampton, M-R Burnham, DL Martin, NM Dowell-Mesfin, JN Turner, W Shain (2007) Functionalized hydrogel surfaces for the patterning of multiple biomolecules. J. Biomed. Mat. Res. Part A 81: 347-354
• Jun, S.B., M.R. Hynd, N. Dowell-Mesfin, K.L. Smith, J.N. Turner, W. Shain, S.J. Kim (2007) Synaptic Connectivity of Low-Density Neuronal Networks Cultured on Patterned Poly-L-Lysine Microelectrode Arrays, J Neurosci Meth 160: 317-326.
• Hynd, MR, JP Frampton, NM Dowell-Mesfin, JN Turner, W Shain (2007) Directed cell growth on protein-functionalized hydrogel surfaces. J. Neurosci. Meth. 162: 255-263
• Lin G, MK Chawla, K Olson, CA Barnes, JF Guzowski, CS Bjornsson, W Shain, B Roysam (2007) A multi-model approach to simultaneous segmentation and classification of heterogeneous populations of cell nuclei in 3D confocal microscope images. Cytometry Part A: 71:724-36.
• Jun, SB, MR Hynd, KL Smith, J/K Lee, JK Song, W Shain, SJ Kim (2007) Electrical stimulation-induced neuronal clustering in cultured neural networks, Med & Biol Engin & Comput 45:1015-1021.
• Williams JC, J Hippensteel, J Dilgen, W Shain, DR Kipke (2007) Complex impedance spectroscopy of monitoring tissue responses to inserted neural implants, J Neural Engin 4:410-423.
• Hynd, MR, JN Turner, W Shain (2007) Applications of hydrogels for neural cell engineering. J. Biomat Sci – Polymer Edition 18:1223-1244.
• Frampton, JP, MR Hynd, JC Williams, ML Schuler, W Shain (2007) Three-dimensional hydrogel cultures for modeling changes in tissue impedance around microfabricated neural probes, J Neural Engin, 4: 399-409
• Bjornsson, CS, Lin, G, Y Al-Kafahi, KL Smith, W Shain (2008) B Roysam, Computer-aided classification of cells in complex brain tissue from 5-channel 3-D confocal datasets, J Neurosci Meth 170:165-178.
• Seggio AM, KS Ellison, M Hynd, W Shain, DM Thompson (2008) Cryopreservation of transfected primary dorsal root ganglia neurons, J Neurosci Meth 173:67-73.
• Jun SB, MR Hynd, NM Dowell-Mesfin, Y Al-Kofahi, B Roysam, W Shain, SJ Kim (2008) Modulation of cultured neural networks using neurotrophin release from hydrogel-coated microelectrode arrays. J of Neural Engin 5:203-13.
• Al-Kafahi, YA, N Dowell-Mesfin, C Pace, W Shain, JN Turner, B Roysam (2008) Improved detection of branching pints in algorithms for automated neuron tracing from 3-D confocal images, CytometryA 73:36-43.
• Jhaveri SJ, MR Hynd, N. Dowell-Mesfin, JN Turner, W Shain, CK Ober (2009) The release of nerve growth factor from HEMA hydrogel coated substrates and its effect on the differentiation of neural cells, Biomacromolecules 10:174-183.
• Kipke, DR, W Shain, G Buzsáki, E Fetz, J Henderson, J Hetke, G Schalk (2008) Advanced neurotechnologies for chronic neural interfaces: New horizons and clinical opportunities, J Neruorsci, 28:11830-11838.
• Roysam, B, W Shain, GA Ascoli (2008) The central role of neuroinformatics in the National Academy of Engineering's Grandest Challenge: Reverse Engineer the Brain, Neuroinformatics 7:1-5.
• Vedam-Mai, V, N Krock, M Ullman, KD Foote, W Shain, KL Smith, AT Yachnis, D Steindler, B Reynolds, S Merritt, F Pagan, J Marjama-Lyons, P Hogarth, AS Resnick, P Zeilman, MS Okun (2010) The National
• DBS Brain Tissue Network Pilot Study: A Need for More Tissue and for More Standardization, Brain, in press
• Hynd, MR, SJ Jhaveri, N Dowel-Mesfin, SB Jun, SB Kim, W Shain, CJ Ober (2009) Release of brain-derived neurotrophic factor from hydrogel-coated neural prosthetic devices, J Biomater, in press
• Narayanaswamy, A, S Dwarakapuram, CS Bjornsson, B Cutler, W Shain, B Roysam (2010) Robust adaptive 3-D segmentation of vessel laminae from fluorescence confocal microscope images and parallel GPU implementation. I IEEE Trans Med Imag 29:583-597
• Frampton, JP, MR Hynd, A Vargun, B Roysam, W Shain (2009) An in vitro System for Modeling Brain Reactive Responses and Changes in Neuroprosthetic Device Impedance. IEEE Trans Biomed Eng, 2009:7155-7158.
• Frampton, JP, MR Hynd, ML Schuler, W Shain (2010) Effects of glial cells on electrode impedance recorded from neural prosthetic devices in vitro. Anal Bioengin, epub.
• Frampton, JP, MR Hynd, ML Schuler, W Shain (2010) Fabrication and optimization of alginate hydrogel constructs for use in 3-D neural cell culture, Biomedical Mat, in press.
• C-L Tsai, JP Lister, CJ Bjornsson, KL Smith, W Shain, CA Barnes, B Roysam (2010) Robust Globally Consistent Multi-image Registration & Montage Synthesis for 3-D Multi-channel Images, J Histol, in press
• Smith, KL, D Johnston, W Shain, AE Anderson(2010) Modulation of Extracellular-Regulated Kinase